Z103
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Z103
Sigma
Zolpidem
≥98% (HPLC), solid
| Synonym: | N,N,6-Trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide |
| CAS Number: | 82626-48-0 |
| Linear Formula: | C19H21N3O |
| Molecular Weight: | 307.39 |
| MDL number: | MFCD00153885 |
| PubChem Substance ID: | 24902172 |
Description
| Biochem/physiol Actions | Potent and selective agonist for the benzodiazepine receptor associated with the GABAA receptor; hypnotic. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| drug control | USDEA Schedule IV; Home Office Schedule 4.1; psychotrope; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada |
| color | white |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL |
| DMSO: 10 mg/mL | |
| ethanol: 50 mg/mL | |
| methanol: 50 mg/mL | |
| H2O: insoluble | |
| dilute aqueous base: insoluble | |
| Gene Information | human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559) |
| rat ... Gabra1(29705), Gabra2(29706), Gabra5(29707), Tspo(24230) |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
| RTECS | NJ5109750 |
References
| reference | Mereu, et al., Reduction of reticulata neuronal activity by zolpidem and alpidem two imidazopyridines with high affinity for type I benzodiazepine receptors. Eur. J. Pharmacol. 179, 339, (1990) Abstract |
| Benavides, et al., Comparitive autoradiographic distribution of central omega (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem. Brain Res. 604, 240-250, (1993) Abstract |
